The thing we are generally concerned about with the image orientation is that with some point and shoot cameras that get mounted on fixed wing (or multirotor) aircraft, if you leave the orientation sensor on it can change values for almost every image. If there is too much twisting around going on, it will cause some issues in the processing. It won't likely be a problem if the orientation changes a few times across the dataset.
We generally recommend turning that sensor off to keep this from happening. It can make reviewing the data for proper overlap almost impossible anyway.